| Pair Name | Betulinic Acid, Doxorubicin | ||
| Phytochemical Name | Betulinic Acid (PubChem CID: 64971 ) | ||
| Anticancer drug Name | Doxorubicin (PubChem CID: 31703 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
MOL
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| Structure of Anticancer Drug |
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MOL
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| Pair Name | Betulinic Acid, Doxorubicin | |||
| Disease Info | [ICD-11: 2A60.Z] | Acute myeloid leukemia | Investigative | |
| Biological Phenomena | Induction-->ROS accumulation | |||
| Gene Regulation | Down-regulation | Expression | BCL2 | hsa596 |
| Up-regulation | Expression | ROS1 | hsa6098 | |
| In Vitro Model | U-937 | Adult acute monocytic leukemia | Homo sapiens (Human) | CVCL_0007 |
| MOLM-13 | Adult acute myeloid leukemia | Homo sapiens (Human) | CVCL_2119 | |
| Result | Dox and the drug combination selectively reduced (p < 0.05) a recently reported anti-apoptotic Bcl-2 protein isoform p15-20-Bcl-2 in MOLM-13 by our group, without affecting the usually reported p26-Bcl-2-α. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Betulinic Acid-Doxorubicin-Drug Combination Induced Apoptotic Death via ROS Stimulation in a Relapsed AML MOLM-13 Cell Model. Antioxidants (Basel). 2021 Sep 14;10(9):1456. doi: 10.3390/antiox10091456. | Click |
